Proteolytic processes in organism of different age rats exposed to xenoestrogens

Abstract Endocrine disrupting chemicals (EDCs) are a group of compounds that affect the endocrine system, frequently found in everyday products and epidemiologically associated with several diseases. The human population is now ubiquitously exposed to EDCs daily life. main way getting xenoestrogens body contaminated food. effects on proteolytic processes different age rats were determination. experiments conducted Wistar exogenous estrogen for 45 days. At beginning experiment 3-month-old pubertal animals 6-month-old sexually mature involved. research materials organ tissue blood serum rats. objects indexes activity trypsin its obligatory inhibitors α 1 - antitrypsin ( 1-AT) 2-macroglobulin 2-MG), cysteine cathepsins B L, molecules middle mass (MMM) level. In summary, eating food by exoestrogens led changes system development endogenous intoxication, which also organ-specific dependent animals: higher level inhibitory link content MMM was observed puberty period, leads decrease potential protective mechanisms organism can become trigger dysfunctional systems natural detoxification biotransformation. Inhibition apoptosis consequence experimental This phenomenon lead inhibit one reject damaged cells from population. Females who more susceptible dietary synthetic estrogens. contrast adult same sex, whose indicators indicate importance characteristics ability perceive xenoestrogens. Rats became less sensitive these substances age. diference due rate pathway reactions, not metabolism estrogens entering body, particular,